An update on diabetic kidney disease, oxidative stress and antioxidant agents

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An update on diabetic kidney disease, oxidative stress and antioxidant agents

Diabetes mellitus is a metabolic disease that is defined by relative or absolute deficiency of insulin secretion. Diabetic kidney disease seems to be one of the most frequent complications of diabetes mellitus. Based on evidence, increased free-radical formation and/or diminished antioxidant defenses induce oxidative stress that is implicated in the pathogenesis of diabetic kidney disease. It i...

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Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease

The increase in the prevalence of diabetes mellitus (DM) and the secondary kidney damage produces diabetic nephropathy (DN). Early nephropathy is defined as the presence of microalbuminuria (30-300 mg/day), including normal glomerular filtration rate (GFR) or a mildly decreased GFR (60-89 mL/min/1.73 m(2)), with or without overt nephropathy. The earliest change caused by DN is hyperfiltration w...

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Antioxidant Therapy for Diabetic Kidney Disease

Diabetic kidney disease (DKD) is the single most common cause of end stage renal disease (ESRD) with the annual costs of caring for patients with DKD exceeding more than $9 billion in the United States (Centers of Disease Control and Prevention, 2005). Every diabetic patient has up to a 40% lifetime risk to develop DKD, if the patient does not die prematurely of cardiovascular disease (CVD) (Pa...

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Betaine as a methyl donor and an antioxidant agent in levodopa-induced hyperhomocysteinemia and oxidative stress in rat's kidney

BACKGROUND: Betaine has been shown to be antioxidantand methyl donor effects in our recent studies. OBJECTIVES: Inthe present study, the antioxidant and methyl donor properties ofbetaine in levodopa/benserazide-mediated hyperhomocysteinemiaand levodopa-induced oxidative stress in rat's kidney wereexamined. METHODS: Sprague-Dawley male rats were dividedinto levodopa (LD), Betaine (Bet.), levodop...

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ژورنال

عنوان ژورنال: Journal of Renal Injury Prevention

سال: 2017

ISSN: 2345-2781

DOI: 10.15171/jrip.2017.30